Synaptic Changes at the Spinal Cord Level and Peripheral Nerve Regeneration During the Course of Muscular Dystrophy in MDX Mice
نویسنده
چکیده
Muscular dystrophies are part of a group of degenerative diseases of the muscular system, which are characterized by muscle degeneration and structural changes at the neuromuscular junction. The most common form is Duchenne Muscular Dystrophy (DMD) (Whitehead et al., 2006), which affects approximately 1 in every 3500 live births (Balaban et al., 2005; Judge et al., 2005; Withehead et al., 2006; Radley et al., 2007). It is a severe X-linked recessive disorder, where the X chromosome is mutated in the region of the gene Xp21, which encodes for the production of dystrophin (Pearce, 2005).
منابع مشابه
Granulocyte-Colony Stimulating Factor Improves MDX Mouse Response to Peripheral Nerve Injury
BACKGROUND G-CSF has been shown to increase neuronal survival, which may positively influence the spinal cord microenvironment during the course of muscular dystrophies. METHODOLOGY/PRINCIPAL FINDINGS Male MDX mice that were six weeks of age received a left sciatic nerve transection and were treated with intraperitoneal injections of 200 µg/kg/day of G-CSF 7 days before and 7 days after the t...
متن کاملTime Course of Axotomy-induced Changes in Synaptophysin Pattern and Synaptic Reaction of Spinal Motoneurons in Adult Rat
Background and Objective: Evaluation of degenerative changes of motoneurons and their related synapses can be useful in understanding the mechanisms of neurodegenerative diseases and their potential treatment. The present electron microscopic and immunohistochemical study investigates the axotomy-induced...
متن کاملGranulocyte colony-stimulating factor (G-CSF) positive effects on muscle fiber degeneration and gait recovery after nerve lesion in MDX mice
BACKGROUND G-CSF has been shown to decrease inflammatory processes and to act positively on the process of peripheral nerve regeneration during the course of muscular dystrophy. AIMS The aims of this study were to investigate the effects of treatment of G-CSF during sciatic nerve regeneration and histological analysis in the soleus muscle in MDX mice. METHODS Six-week-old male MDX mice unde...
متن کاملWhy does the central nervous system not regenerate after injury?
A major problem for neuroscientists and clinicians is why the central nervous system shows ineffective regeneration after injury. Injured peripheral nerve fibers reform their connections, whereas those in injured spinal cord never re-grow. Insights into the mechanisms for repair and restoration of function after spinal cord injury have been obtained by experiments showing that injured nerve cel...
متن کاملWhy does the central nervous system not regenerate after injury?
A major problem for neuroscientists and clinicians is why the central nervous system shows ineffective regeneration after injury. Injured peripheral nerve fibers reform their connections, whereas those in injured spinal cord never re-grow. Insights into the mechanisms for repair and restoration of function after spinal cord injury have been obtained by experiments showing that injured nerve cel...
متن کامل